反应详情

Under a nitrogen atmosphere, treat 1,1-dimethylethyl 1-(4-chlorophenyl)-2-isopropyl-2,7-diazaspiro[3.5]nonane-7-carboxylate (2.74 g) in dry CH2Cl2 (10 mL) with trifluoroacetic acid (2×5 mL) at RT for 45 min. Concentrate the reaction mixture in vacuo. Add CH2Cl2 (10 mL) and concentrate in vacuo (three times) to give a viscous colorless oil (5.76 g). Partition this oil between CH2Cl2 and 1N NaOH. Concentrate the dried (MgSO4) CH2Cl2 solution in vacuo to give the title compound (1.37 g) as a viscous oil.

1. concentrationConcentrate the reaction mixture in vacuo
2. concentrationAdd CH2Cl2 (10 mL) and concentrate in vacuo (three times)