Hydrochloric Acid → Hydrochloric Acid

HRID 1869458Notes

Reaction equation

HRID 1869458 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>CO.O1CCOCC1>[CH3:30][S:27]([C:24]1[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]2[N:18]=[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[S:15][CH:16]=2)=[CH:26][CH:25]=1)(=[O:28])=[O:29].[ClH:31]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 250241364-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Product 2

HCID 313Hydrochloric AcidHCID 579868424-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (615 mg, 1.36 mmol) in methanol (10 mL) was treated with 10 mL of 4N HCl in dioxane. The resulting solution was stirred at room temperature for 30 minutes. Then all the solvents were removed in vacuo to afford the desired product as a HCl salt.

Workup

  1. customThen all the solvents were removed in vacuo

Sources & evidence

ORD record
ord-6909620a01e84f808e4b12cb5f92979c
Source dataset
uspto-grants-2009_12
Patent number
US07638541B2

Reaction notes

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