Hydrochloric Acid → Hydrochloric Acid

HRID 1869509Notes

Reaction equation

HRID 1869509 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[S:14][CH:15]=[C:16]([CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH:30]=[N:29][N:28]=[N:27]4)=[CH:22][CH:21]=3)[N:17]=2)[CH2:9]1)=O)(C)(C)C.[ClH:31]>ClCCl.CO.O1CCOCC1>[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]2[S:14][CH:15]=[C:16]([CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]([N:26]4[CH:30]=[N:29][N:28]=[N:27]4)=[CH:24][CH:25]=3)[N:17]=2)[CH2:9]1.[ClH:31]

Participants

7

Reactant 2

HCID 313Hydrochloric AcidHCID 579868933-[4-(4-Tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 2

HCID 313Hydrochloric AcidHCID 57986925HCID 57986925, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-[4-(4-Tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (from Example 102) (411 mg, 0.959 mmol) in dichloromethane (10 mL) and methanol (2 mL) were treated with 1 mL of 4N HCl in dioxane. The resulting solution was stirred at room temperature for 30 minutes. The solvents were removed in vacuo to afford the desired product as an HCl salt.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-5657a0dc66854f2289729c60502945cb
Source dataset
uspto-grants-2009_12
Patent number
US07638541B2

Reaction notes

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