5-(Methoxycarbonyl)thiophene-2-carboxylic acid → 5-[1-(3-Trifluoromethoxy-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester
Reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6]([CH:10]([NH2:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1.[CH3:15][O:16][C:17]([C:19]1[S:20][C:21]([C:24](O)=[O:25])=[CH:22][CH:23]=1)=[O:18]>>[CH3:15][O:16][C:17]([C:19]1[S:20][C:21]([C:24](=[O:25])[NH:12][CH:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:13])([F:14])[F:1])[CH:5]=2)[CH3:11])=[CH:22][CH:23]=1)=[O:18]Participants
3
Procedure
The title compound was prepared in an analogous manner to that described in example 1, step 2 from 1-(3-trifluoromethoxy-phenyl)-ethyl amine and thiophene-2,5-dicarboxylic acid monomethyl ester.
Sources & evidence
- ORD record
- ord-d0fa7f447470432d8c6938ef7efd029f
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07638553B2
Reaction notes
Loading…