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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1869539Generated: October 30, 2026

5-(Methoxycarbonyl)thiophene-2-carboxylic acid → 5-[1-(3-Trifluoromethoxy-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/1869539

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methoxycarbonyl)thiophene-2-carboxylic acidHCID 818352—
Reactant1-[3-(Trifluoromethoxy)phenyl]ethan-1-amineHCID 22605542—
Product5-[1-(3-Trifluoromethoxy-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl esterHCID 69052819—

Reaction Steps

The title compound was prepared in an analogous manner to that described in example 1, step 2 from 1-(3-trifluoromethoxy-phenyl)-ethyl amine and thiophene-2,5-dicarboxylic acid monomethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07638553B2
Source datasetuspto-grants-2009_12
ORD IDord-d0fa7f447470432d8c6938ef7efd029f
Source noteuspto-grants-2009_12