Hydrogen Bromide → HCID 86619556, compound

Participants

Reaction Steps

0.5 g of (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (chemical purity: 85%, 0.59 mmol) are dissolved in 5 ml of ethanol at ambient temperature and combined with 235 μl hydrobromic acid (30% in glacial acetic acid), whereupon a white precipitate is immediately formed. The suspension is stirred for 5 hours at ambient temperature, diluted with a little ethanol and filtered. The isolated solid is dried for 12 hours at 70° C.

Provenance & Evidence