Hydrogen Bromide → HCID 86619556, compound

HRID 1869591Notes

Reaction equation

HRID 1869591 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:34][C:35]3[CH:40]=[C:39]([C:41]([F:44])([F:43])[F:42])[C:38]([NH2:45])=[C:37]([Cl:46])[CH:36]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:47]=[CH:48][CH:49]=[CH:50][C:4]=2[NH:3]1.[BrH:51]>C(O)C>[BrH:51].[BrH:51].[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:34][C:35]3[CH:40]=[C:39]([C:41]([F:43])([F:42])[F:44])[C:38]([NH2:45])=[C:37]([Cl:46])[CH:36]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:47]=[CH:48][CH:49]=[CH:50][C:4]=2[NH:3]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 11629090HCID 11629090, compound

Product 1

HCID 86619556HCID 86619556, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.5 g of (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (chemical purity: 85%, 0.59 mmol) are dissolved in 5 ml of ethanol at ambient temperature and combined with 235 μl hydrobromic acid (30% in glacial acetic acid), whereupon a white precipitate is immediately formed. The suspension is stirred for 5 hours at ambient temperature, diluted with a little ethanol and filtered. The isolated solid is dried for 12 hours at 70° C.

Workup

  1. customis immediately formed
  2. filtrationfiltered
  3. customThe isolated solid is dried for 12 hours at 70° C.

Sources & evidence

ORD record
ord-c0a83f957aa746dca729c06bae08e089
Source dataset
uspto-grants-2009_12
Patent number
US07638625B2

Reaction notes

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