反应详情

温度

5 °C

0.25 g (0.38 mmol) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide and 86.2 mg (0.38 mmol) naphthalene-2-sulphonic acid monohydrate are suspended in 5 ml isopropanol and refluxed. The solution is cooled to ambient temperature within 6 days in 5° C. stages and filtered. The isolated solid is washed with isopropanol and dried for 12 hours at 60° C.

1. temperaturerefluxed
2. filtrationfiltered
3. washThe isolated solid is washed with isopropanol
4. customdried for 12 hours at 60° C.