反应详情

1,1-Dimethylethyl 4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 5) (5.7 g) was stirred in a solution of HCl-Dioxane (100 ml, 4M) for 1 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D6) as a pale yellow oil which solidified on standing (3.04 g).

1. customThe solvent was evaporated
2. dissolutionthe resultant yellow solid was dissolved in saturated potassium carbonate (25 ml)
3. extractionThe solution was extracted into dichloromethane (3×50 ml)
4. dry with materialthe combined organics dried (MgSO4)
5. customevaporated