1,1-Dimethylethyl 4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinecarboxylate → 1-Cyclobutyl-4-(4-piperidinylmethyl)piperidine

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Reaction Steps

1,1-Dimethylethyl 4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 5) (5.7 g) was stirred in a solution of HCl-Dioxane (100 ml, 4M) for 1 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D6) as a pale yellow oil which solidified on standing (3.04 g).

Provenance & Evidence