Hydrochloric Acid → 5-{4-[(1-Cyclobutyl4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylic acid hydrochloride

Participants

Reaction Steps

Methyl 5-{4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylate (may be prepared as described in Example 1) (0.665 g) was dissolved in conc. HCl and heated at reflux for 1.5 h. The reaction mixture was evaporated, then re-evaporated from toluene (3×10 ml) to afford the crude acid hydrochloride salt (E5) as a yellow solid (0.705 g). MS electrospray (+ion) 359 (MH+)

Provenance & Evidence