Hydrochloric Acid → 5-{4-[(1-Cyclobutyl4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylic acid hydrochloride

HRID 1869637Notes

Reaction equation

HRID 1869637 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[N:19]=[CH:20][C:21]([C:24]([O:26]C)=[O:25])=[N:22][CH:23]=4)[CH2:14][CH2:13]3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:28]>>[ClH:28].[CH:1]1([N:5]2[CH2:6][CH2:7][CH:8]([CH2:11][CH:12]3[CH2:13][CH2:14][N:15]([C:18]4[N:19]=[CH:20][C:21]([C:24]([OH:26])=[O:25])=[N:22][CH:23]=4)[CH2:16][CH2:17]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11501627Methyl 5-{4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylate

Product 1

HCID 688871335-{4-[(1-Cyclobutyl4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylic acid hydrochloride

Procedure

Methyl 5-{4-[(1-cyclobutyl-4-piperidinyl)methyl]-1-piperidinyl}-2-pyrazinecarboxylate (may be prepared as described in Example 1) (0.665 g) was dissolved in conc. HCl and heated at reflux for 1.5 h. The reaction mixture was evaporated, then re-evaporated from toluene (3×10 ml) to afford the crude acid hydrochloride salt (E5) as a yellow solid (0.705 g). MS electrospray (+ion) 359 (MH+)

Workup

  1. temperatureheated
  2. temperatureat reflux for 1.5 h
  3. customThe reaction mixture was evaporated
  4. customre-evaporated from toluene (3×10 ml)

Sources & evidence

ORD record
ord-fed2e5c7b3b14298a4064c36277c4e36
Source dataset
uspto-grants-2009_12
Patent number
US07638631B2

Reaction notes

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