Methylamine → N-Methyl-5-(4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-pyridinecarboxamide
Reaction equation
[CH3:1][CH:2]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[CH:19][C:20]([C:23](OC(C)(C)C)=[O:24])=[N:21][CH:22]=3)[CH2:13][CH2:12]2)[CH2:6][CH2:5]1)[CH3:3].[CH3:30][NH2:31]>>[CH3:30][NH:31][C:23]([C:20]1[CH:19]=[CH:18][C:17]([N:14]2[CH2:13][CH2:12][CH:11]([CH2:10][CH:7]3[CH2:8][CH2:9][N:4]([CH:2]([CH3:3])[CH3:1])[CH2:5][CH2:6]3)[CH2:16][CH2:15]2)=[CH:22][N:21]=1)=[O:24]Participants
3
Procedure
N-Methyl-5-(4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-pyridinecarboxamide was prepared using an analogous process to that described in Examples 10 and 11 from 1,1-dimethylethyl 5-(4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-pyridinecarboxylate (may be prepared as described in Example 4) and methylamine. The compound displayed 1H-NMR and mass spectral data that were consistent with structure. MS electrospray (+ion) 359 (MH+).
Sources & evidence
- ORD record
- ord-ff151268f40142b3907cde7b4fa3adef
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07638631B2
Reaction notes
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