5-Bromo-2-(trifluoromethyl)pyrimidine → 5-(4-{[1-(1-Methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-(trifluoromethyl)pyrimidine

HRID 1869644Notes

Reaction equation

HRID 1869644 reaction equation
[CH3:1][CH:2]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:6][CH2:5]1)[CH3:3].Br[C:18]1[CH:19]=[N:20][C:21]([C:24]([F:27])([F:26])[F:25])=[N:22][CH:23]=1>>[CH3:3][CH:2]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([C:18]3[CH:19]=[N:20][C:21]([C:24]([F:27])([F:26])[F:25])=[N:22][CH:23]=3)[CH2:15][CH2:16]2)[CH2:6][CH2:5]1)[CH3:1]

Participants

3

Reactant 2

HCID 336979635-Bromo-2-(trifluoromethyl)pyrimidineHCID 688858081-(1-Methylethyl)-4-(4-piperidinylmethyl)piperidine

Product 1

HCID 116607095-(4-{[1-(1-Methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-(trifluoromethyl)pyrimidine

Procedure

Example 36 was prepared using an analogous process to that described in Example 35 from 1-(1-methylethyl)-4-(4-piperidinylmethyl)piperidine (may be prepared as described in Description 4) and 5-bromo-2-trifluoromethylpyrimidine (may be prepared as described in F. Cottet and M. Schlosser, Eur. J. Org. Chem., 2002, 327). 1H-NMR and mass spectral data were consistent with structure. MS electrospray (+ion) 371 (MH+).

Workup

  1. customExample 36 was prepared

Sources & evidence

ORD record
ord-fa4363bd7ede46358a204c4a03145d15
Source dataset
uspto-grants-2009_12
Patent number
US07638631B2

Reaction notes

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