5-Bromo-2-(trifluoromethyl)pyrimidine → 5-(4-{[1-(1-Methylethyl)-4-piperidinyl]methyl}-1-piperidinyl)-2-(trifluoromethyl)pyrimidine

Participants

Reaction Steps

Example 36 was prepared using an analogous process to that described in Example 35 from 1-(1-methylethyl)-4-(4-piperidinylmethyl)piperidine (may be prepared as described in Description 4) and 5-bromo-2-trifluoromethylpyrimidine (may be prepared as described in F. Cottet and M. Schlosser, Eur. J. Org. Chem., 2002, 327). 1H-NMR and mass spectral data were consistent with structure. MS electrospray (+ion) 371 (MH+).

Provenance & Evidence