HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → (2S,4R)-1-((1R)-1-(4-Chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidine-4-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | 1-Bromo-3-methylbutane | HCID 7891 | — |
| Reactant | (+)-methyl{(2S,4R)-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate | HCID 86617999 | — |
| Product | (2S,4R)-1-((1R)-1-(4-Chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidine-4-acetic acid | HCID 57987388 | — |
Reaction Steps
The compound was prepared analogously to Example 160 using the Grignard reagent derived from 1-bromo-3-methylbutane, starting with the chiral piperidine of Example 114 Step 1 and replacing 4-(trifluoromethyl)benzaldehyde with 4-chlorobenzaldehyde. M/Z (ES+) 482 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07638629B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-376732b3025e466787239d5dca6a7987 |
| Source note | uspto-grants-2009_12 |