反应详情

A solution of 8-[(cyclopropyl-methyl-amino)-methyl]-2,2,4,4-tetramethyl-6-trimethylsilanylethynyl chroman (Intermediate 10, 0.729 g, 1.97 mmol) in methanol (30 mL) was treated with potassium carbonate (1.4 g, 10.2 mmol) and the resulting reaction mixture was stirred at ambient temperature overnight. The solvent was evaporated in vacuo, the residue was diluted with water and extracted with ethyl acetate. The organic phase dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as a brown oil (0.571 g, 98%).

1. customthe resulting reaction mixture
2. customThe solvent was evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic phase dried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo