反应详情

温度

80 °C

A solution of 6-bromo-8-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 18, 0.47 g, 1.56 mmol) in methanol (5 mL) was treated with potassium carbonate (0.2 g, 1.45 mmol) and the resulting reaction mixture was heated at 80° C. for 3 h. The solvent was evaporated in vacuo, the residue was diluted with water and extracted with ethyl acetate. The organic phase dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as a brown oil (0.35 g, 99%).

1. customthe resulting reaction mixture
2. customThe solvent was evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic phase dried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo