反应详情

A solution of [4-(8-hydroxy-2,2,4,4-tetramethyl-chroman-6-ylethynyl)-phenyl]-acetic acid methyl ester (Intermediate 20, 0.02 g, 0.076 mmol) in acetone (2 mL) was treated with potassium carbonate (0.026 g, 0.19 mmol) and 2-iodopropane (5 mL, large excess) and the resulting reaction mixture was refluxed for 30 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as an oil (0.02 g, 91%).

1. customthe resulting reaction mixture
2. temperaturewas refluxed for 30 h
3. customThe volatiles were evaporated in vacuo
4. additionthe residue was diluted with water
5. extractionextracted with ethyl acetate
6. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated in vacuo