反应详情

A solution 2-[(cyclopropyl-methyl-amino)-methyl]-4-trimethylsilanylethynyl-benzoic acid isopropyl ester (Intermediate 121, 0.34 g, 1 mmol) in methanol (2 mL) was treated with potassium carbonate (0.207 g, 1.5 mmol) and the resulting reaction mixture was stirred at ambient temperature for 4 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as an oil (0.21 g, 78%).

1. customthe resulting reaction mixture
2. customThe volatiles were evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with diethyl ether
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo