Hydrochloric Acid → 1-(Tetrahydro-2H-pyran-4-yl)ethanone
Reaction equation
[C:1]([C:4]1(C(OC)=O)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].Cl>>[C:1]([CH:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2]Participants
3
Procedure
In a flask made of glass having an inner volume of and equipped with a stirring device, a thermometer and a reflux condenser were charged 0.38 g (2.0 mmol) of 4-acetyl-4-methoxycarbonyltetrahydropyran with a purity of 99% and synthesized in the same manner as in Reference example 1 and 2.52 ml (10 mmol) of 4 mol/l hydrochloric acid, and the mixture was reacted at 120° C. for 4 hours with stirring. After completion of the reaction, when the reaction mixture was analyzed by gas chromatography (Internal standard method), 0.23 g (Reaction yield: 90%) of 4-acetyltetrahydropyran was found to be formed.
Workup
- customIn a flask made of glass
- customequipped with a stirring device
- customthe mixture was reacted at 120° C. for 4 hours
- customAfter completion of the reaction, when the reaction mixture
Sources & evidence
- ORD record
- ord-e4db30bf22b849cd9be96bbcb7bf1242
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741497B2
Reaction notes
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