HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-(5-fluoro-4-methyl-2-nitrophenyl)glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Reactant | 1,5-Difluoro-2-methyl-4-nitrobenzene | HCID 18695459 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(5-fluoro-4-methyl-2-nitrophenyl)glycine ethyl ester | HCID 18695409 | 61% |
Reaction Steps
By using 3.00 g of 2,4-difluoro-5-nitrotoluene, 8.77 g of triethylamine, 40 ml of DMF, 40 ml of THF and 2.42 g of glycine ethyl ester hydrochloride, 2.70 g (61%) of N-(5-fluoro-4-methyl-2-nitrophenyl)glycine ethyl ester was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06096743 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-2a9d892578fa485aa4a12b1bbde2cdd6 |
| Source note | uspto-grants-2000_08 |