Imidazole → N-[5-(1H-imidazol-1-yl)-4-methyl-2-nitrophenyl]glycine ethyl ester

HRID 1870202Notes

Reaction equation

HRID 1870202 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([CH3:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:10]([CH3:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695409N-(5-fluoro-4-methyl-2-nitrophenyl)glycine ethyl ester

Product 1

HCID 18695445N-[5-(1H-imidazol-1-yl)-4-methyl-2-nitrophenyl]glycine ethyl esterYield 39.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

By using 1.00 g of N-(5-fluoro-4-methyl-2-nitrophenyl)glycine ethyl ester, 266 mg of imidazole and 10 ml of pyridine, 470 mg (39%) of N-[5-(1H-imidazol-1-yl)-4-methyl-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-78bc6a8411cb460baf1d14aa8bc55706
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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