HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 18695448, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Bromo-2,4-difluoro-5-nitrobenzene | HCID 223078 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18695448 | HCID 18695448 | 65.9% |
Reaction Steps
By using 7.61 g (54.5 mmol) of glycine ethyl ester hydrochloride, 15 ml of THF, 7.64 ml of triethylamine, 10 ml of DMF and 11.8 g (49.6 mmol) of 5-bromo-2,4-difluoronitrobenzene, 10.5 g (60%) of N-(4-bromo-5-fluoro-2-nitrophenyl)glycine ethyl ester was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06096743 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-5d4a56786a0c49f0bc3a805628653138 |
| Source note | uspto-grants-2000_08 |