Tetrahydrofuran → HCID 18695448, compound

HRID 1870207Notes

Reaction equation

HRID 1870207 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].C1COCC1.C(N(CC)CC)C.[Br:21][C:22]1[C:23]([F:32])=[CH:24][C:25](F)=[C:26]([N+:28]([O-:30])=[O:29])[CH:27]=1>CN(C=O)C>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:25]1[CH:24]=[C:23]([F:32])[C:22]([Br:21])=[CH:27][C:26]=1[N+:28]([O-:30])=[O:29])[CH3:3]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 2230781-Bromo-2,4-difluoro-5-nitrobenzeneHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 18695448HCID 18695448, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using 7.61 g (54.5 mmol) of glycine ethyl ester hydrochloride, 15 ml of THF, 7.64 ml of triethylamine, 10 ml of DMF and 11.8 g (49.6 mmol) of 5-bromo-2,4-difluoronitrobenzene, 10.5 g (60%) of N-(4-bromo-5-fluoro-2-nitrophenyl)glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-5d4a56786a0c49f0bc3a805628653138
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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