Imidazole → HCID 18695402, compound

HRID 1870208Notes

Reaction equation

HRID 1870208 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([Br:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:10]([Br:14])=[CH:9][C:8]=1[N+:15]([O-:17])=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695448HCID 18695448, compound

Product 1

HCID 18695402HCID 18695402, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.33 (3H, t, J=7.4 Hz), 4.04 (2H, d, J=4.9 Hz), 4.30 (2H, q, J=7.4 Hz), 6.46 (1H, d, J=10.9 Hz), 8.44 (1H, d, J=7.3 Hz), 8.49 (1H, bs). 2) By using 3.36 g (10.5 mmol) of N-(4-bromo-5-fluoro-2-nitrophenyl)glycine ethyl ester, 2.86 g of imidazole and 20 ml of DMF, 3.50 g (90%) of N-[4-bromo-5-(1H-imidazol-1-yl)-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-d128d27c425e4da5a70ae68417f7b4af
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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