Imidazole → HCID 18695421, compound

HRID 1870209Notes

Reaction equation

HRID 1870209 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([O:14][CH3:15])=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17])[CH3:2].[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[C:10]([O:14][CH3:15])=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695471HCID 18695471, compound

Product 1

HCID 18695421HCID 18695421, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using 420 mg of N-(5-fluoro-4-methoxy-2-nitrophenyl)glycine ethyl ester, 420 mg of imidazole and 2.5 ml of DMF, 200 mg (41%) of N-[5-(1H-imidazol-1-yl)-4-methoxy-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-ff7bc0324a734852b6b9e7dae10ce81f
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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