Imidazole → HCID 18695450, compound

HRID 1870212Notes

Reaction equation

HRID 1870212 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][NH:6][C:7]1[CH:12]=[C:11](F)[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:8]=1[N+:18]([O-:20])=[O:19])[CH3:2].[NH:22]1[CH:26]=[CH:25][N:24]=[CH:23]1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([N:22]2[CH:26]=[CH:25][N:24]=[CH:23]2)[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:8]=1[N+:18]([O-:20])=[O:19])[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18695454HCID 18695454, compound

Product 1

HCID 18695450HCID 18695450, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.15-1.55 (3H, m), 3.19 (3H, s), 3.93-4.50 (4H, m), 6.49 (1H, d, J=12.0 Hz), 8.76-9.07 (2H, m). 2) By using 1.00 g of N-(5-fluoro-4-methylsulfonyl-2-nitrophenyl)glycine ethyl ester, 0.85 g of imidazole and 5 ml of DMF, 0.35 g (67%) of N-[5-(1H-imidazol-1-yl)-4-methylsulfonyl-2-nitrophenyl]glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-703d9f177626436ca469dd390ab4422f
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

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