2-Thiophenemethanol → HCID 54470557, compound

HRID 1870237Notes

Reaction equation

HRID 1870237 reaction equation
[Cl:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]=[C:11]=[O:12].[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH2:18][OH:19]>>[Cl:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=1[NH:10][C:11](=[O:12])[O:19][CH2:18][C:14]1[S:13][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 694672-ThiophenemethanolHCID 18695876HCID 18695876, compound

Product 1

HCID 54470557HCID 54470557, compound

Procedure

2-Chloromethyl-1-isocyanato-3-methylbenzene (2.5 g) and thiophenemethanol (1.57 g) are combined and stirred at RT. When crystallization commences, petroleum ether 50/70 (20 ml) is added and the suspension is stirred for 16 h at RT. After filtration and washing with diethyl ether, 2.57 g (63%) of the title compound are obtained as a solid of m.p. 111-114° C.

Workup

  1. customWhen crystallization commences, petroleum ether 50/70 (20 ml)
  2. additionis added
  3. stirringthe suspension is stirred for 16 h at RT
  4. filtrationAfter filtration
  5. washwashing with diethyl ether, 2.57 g (63%) of the title compound
  6. customare obtained as a solid of m.p. 111-114° C.

Sources & evidence

ORD record
ord-707d5707cc08491081812d79b16f0f9b
Source dataset
uspto-grants-2000_08
Patent number
US06096758

Reaction notes

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