Hydrochloric Acid → HCID 11784360, compound

HRID 1870255Notes

Reaction equation

HRID 1870255 reaction equation
C[O:2][C:3]([CH2:5][CH:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]([C:17](=[O:29])[C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH2:25][CH2:26][CH3:27])=[CH:20][C:19]=2[Cl:28])[CH2:9][CH2:8][CH2:7]1)=[O:4].[OH-].[Na+].Cl>C(O)C>[C:3]([CH2:5][CH:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]([C:17](=[O:29])[C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH2:25][CH2:26][CH3:27])=[CH:20][C:19]=2[Cl:28])[CH2:9][CH2:8][CH2:7]1)([OH:4])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15895925HCID 15895925, compound

Product 1

HCID 11784360HCID 11784360, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The above product, 5-methoxycarbonylmethyl-1-(4-n-propylamino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (880 mg) is dissolved in ethanol (20 ml), and thereto is added a 6N aqueous sodium hydroxide solution (1 ml), and the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid, and extracted with ethyl acetate. The extract is dried, and concentrated to give 5-carboxymethyl-1-(4-n-propylamino-2-chlorobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (800 mg) as a white powder.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe extract is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-98369b32a4f84ad586e8b4e332d469a4
Source dataset
uspto-grants-2000_08
Patent number
US06096736

Reaction notes

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