3-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazole → 3-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochloride

HRID 1870273Notes

Reaction equation

HRID 1870273 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>>[ClH:21].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

3

Reactant 2

HCID 154539363-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazoleHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 186960233-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochlorideYield 190.8%

Procedure

To 3-(2-(N-t-butoxycarbonylamino)-ethoxy)-5-chloro-1,2-benzisoxazole (0.50 g) was added a solution of 4 N-hydrochloric acid/1,4-dioxane (4.0 ml) and stirred at room temperature for 15 minutes. After filtering the precipitated crystals and washing with 1,4-dioxane, the title compound (0.38 g) was obtained as colorless crystals.

Workup

  1. filtrationAfter filtering the precipitated crystals
  2. washwashing with 1,4-dioxane

Sources & evidence

ORD record
ord-5d1bc17ec8e94ee3be2cf1a1818d5cf0
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

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