Hydrochloric Acid → HCID 178518993, compound

HRID 1870276Notes

Reaction equation

HRID 1870276 reaction equation
[OH-].[Na+].Cl[C:4]1[C:9]([C:10]([NH:12][OH:13])=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1.Cl>>[OH:11][C:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[N:5][C:4]=2[O:13][N:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4360945HCID 4360945, compound

Product 1

HCID 178518993HCID 178518993, compoundYield 81.9%

Procedure

To 10% aqueous sodium hydroxide solution (26 ml) was added 2-chloropyridine-3-carbohydroxamic acid (2.60 g) and refluxed for 30 minutes. After pH was adjusted to 2.0 with 6N-hydrochloric acid under ice cooling, the reaction mixture was left to stand for 30 minutes at the same temperature. The title compound (1.68 g) was obtained by filtering the precipitated crystals and washing with water and then with a methanol-ether mixture (1:1).

Workup

  1. temperaturerefluxed for 30 minutes
  2. waitthe reaction mixture was left

Sources & evidence

ORD record
ord-8c4ab994fc704b8d800e91ff5a69753f
Source dataset
uspto-grants-2000_08
Patent number
US06096771

Reaction notes

Loading…