Methyl L-phenylalaninate hydrochloride → HCID 15484848, compound

HRID 1870313Notes

Reaction equation

HRID 1870313 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:6].[Cl:15][C:16]1[CH:17]=[C:18]([NH:23][CH:24]([C:26](O)=[O:27])[CH3:25])[CH:19]=[CH:20][C:21]=1[Cl:22]>CCOC(C)=O>[CH3:2][O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH:6][C:26](=[O:27])[C@H:24]([CH3:25])[NH:23][C:18]1[CH:19]=[CH:20][C:21]([Cl:22])=[C:16]([Cl:15])[CH:17]=1

Participants

4

Reactant 2

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 69164262-(3,4-Dichloro-phenylamino)-propionic Acid

Product 1

HCID 15484848HCID 15484848, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure D and using L-phenylalanine methyl ester hydrochloride (Sigma) and N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above), the title compound was prepared as a solid (mp=122-124.5° C.). The reaction was monitored by tlc (Rf=0.47 in 1:1 EtOAc:Hexanes) and the product was purified by flash chromatography using 1:1 EtOAc:Hexanes as the eluent.

Workup

  1. customthe product was purified by flash chromatography

Sources & evidence

ORD record
ord-aee5d0911cda4415b29cb1ee03d26f7e
Source dataset
uspto-grants-2000_08
Patent number
US06096782

Reaction notes

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