反应详情

To 4-phenyl-1-(4-cyanophenyl)piperidine (0.39 g) are added acetic acid (10 ml) and conc. hydrochloric acid (10 ml), and the mixture is refluxed for five hours. The reaction solution is concentrated, and to the residue is added diethyl ether/methanol. The insoluble crystals are collected by filtration, and dried under reduced pressure to give 4-phenyl-1-(4-carboxyphenyl)piperidine (0.39 g) as white powder.

1. temperaturethe mixture is refluxed for five hours
2. concentrationThe reaction solution is concentrated
3. additionto the residue is added diethyl ether/methanol
4. filtrationThe insoluble crystals are collected by filtration
5. customdried under reduced pressure