Iodoethane → 1-Ethyl-1,4-diazepane

HRID 1870443Notes

Reaction equation

HRID 1870443 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:8](I)[CH3:9]>C(O)C>[CH2:8]([N:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH3:9]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 68163Hexahydro-1,4-diazepine

Product 1

HCID 75775381-Ethyl-1,4-diazepane

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Homopiperazine (100 g) is dissolved in ethanol (500 ml), and thereto is added dropwise gradually ethyl iodide (19.8 ml). The mixture is stirred at room temperature overnight, and the insoluble materials are removed by filtration. The filtrate is evaporated to remove the solvent. Purification is perfomed by distillation to give 1-ethylhomopiperazine (50 g) as colorless oil.

Workup

  1. customthe insoluble materials are removed by filtration
  2. customThe filtrate is evaporated
  3. customto remove the solvent
  4. customPurification
  5. distillationis perfomed by distillation

Sources & evidence

ORD record
ord-b3bb1b1b920c4806916a33f60a9faecb
Source dataset
uspto-grants-2000_08
Patent number
US06096735

Reaction notes

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