反应详情

A mixture of the title compound of Example 2 (200 mg, 1.37 mmol), thionyl chloride (500 μl, 6.85 mmol) and DMF (20 μl) in dry methylene chloride was refluxed for 2 hours. The solvents were evaporated and the residue dried in vacuo to give 183 mg (81%) of the title product as a brown solid, mp 123-5 C. 1H-NMR (CDCl3): δ7.74 (m, 1 H), 6.64 (m, 1H),). GC-MS (m/e, %) 166/164 (M+, 11), 129(100).

1. temperaturewas refluxed for 2 hours
2. customThe solvents were evaporated
3. customthe residue dried in vacuo