Benzylamine → HCID 18696619, compound

HRID 1870546Notes

Reaction equation

HRID 1870546 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2=O)=[CH:5][CH:4]=1.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]=[C:10]2[NH:21][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one

Product 1

HCID 18696619HCID 18696619, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture containing 7-methoxytetralone (25.0 g), benzylamine (15.8 mL), toluene and 4 Å molecular sieves (42.0 g) was heated at reflux for 3.5 h. The mixture was cooled to room temperature, filtered through a layer of Florisil® and concentrated under reduced pressure to yield 42.1 g of crude title compound of Step A.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 h
  3. filtrationfiltered through a layer of Florisil®
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-da348ce8b2214c5aacc31e91c5f6c908
Source dataset
uspto-grants-2000_08
Patent number
US06096895

Reaction notes

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