Hydrochloric Acid → HCID 178479103, compound

HRID 1870676Notes

Reaction equation

HRID 1870676 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]2[C:12]([OH:13])=[CH:11][CH:10]=[N:9][C:8]=12)([O-])=O.C1CCCCC=1.[ClH:20]>[Pd].C(O)(=O)C>[ClH:20].[NH2:1][C:4]1[CH:5]=[N:6][N:7]2[C:12]([OH:13])=[CH:11][CH:10]=[N:9][C:8]=12

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 8079CyclohexeneHCID 178526869HCID 178526869, compound

Product 1

HCID 178479103HCID 178479103, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

0.35 g of 3-nitropyrazolo[1,5-a]pyrimidin-7-ol, 20 cc of acetic acid, 1.6 g of cyclohexene and 85 mg of 10% palladium-on-charcoal were introduced into a 50 cc 3-necked round-bottomed flask fitted with a magnetic stirrer and equipped with a condenser and a thermometer. The medium was refluxed for 1h30' and the catalyst was then filtered off through Celite. After evaporation of the acetic acid, the solid obtained was taken up in 2 cc of refluxing concentrated hydrochloric acid for 2 h 30'. After evaporation of the solvent, an off-white solid was collected.

Workup

  1. customfitted with a magnetic stirrer
  2. customequipped with a condenser
  3. temperatureThe medium was refluxed for 1h30' and the catalyst
  4. filtrationwas then filtered off through Celite
  5. customAfter evaporation of the acetic acid
  6. customthe solid obtained
  7. customAfter evaporation of the solvent
  8. customan off-white solid was collected

Sources & evidence

ORD record
ord-8108f15a248e4f8889756f2525ef3b60
Source dataset
uspto-grants-2000_08
Patent number
US06099593

Reaction notes

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