Ethanolamine → HCID 54397096, compound

HRID 1870678Notes

Reaction equation

HRID 1870678 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1.[CH2:15]([CH2:17][NH2:18])[OH:16]>C(O)C>[OH:16][CH2:15][CH2:17][NH:18][C:2]1[N:7]2[N:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:6]2[N:5]=[C:4]([CH3:14])[CH:3]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 22676971HCID 22676971, compound

Product 1

HCID 54397096HCID 54397096, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15 g of 7-chloro-5-methyl-3-nitropyrazolo[1,5-a]pyrimidine in 100 cc of ethanol were introduced into a 250 cc three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer and a condenser. 5 g of ethanolamine were added dropwise and the medium was refluxed for 30 minutes. After cooling to room temperature, the yellow precipitate was filtered off. This precipitate was rinsed with diisopropyl ether. After drying under vacuum over phosphorus pentoxide, 14.2 g of 7-β-hydroxyethylamino-5-methyl-3-nitropyrazolo[1,5-a]pyrimidine were obtained in the form of yellow crystals. (Yield=86%, melting point=231° C.).

Workup

  1. customequipped with a magnetic stirrer
  2. temperaturethe medium was refluxed for 30 minutes
  3. filtrationthe yellow precipitate was filtered off
  4. washThis precipitate was rinsed with diisopropyl ether
  5. dry with materialAfter drying under vacuum over phosphorus pentoxide

Sources & evidence

ORD record
ord-47ba908dc58c4ca18fd193d42d60a8ef
Source dataset
uspto-grants-2000_08
Patent number
US06099593

Reaction notes

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