Ethanolamine → HCID 54397096, compound

Participants

Reaction Steps

15 g of 7-chloro-5-methyl-3-nitropyrazolo[1,5-a]pyrimidine in 100 cc of ethanol were introduced into a 250 cc three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer and a condenser. 5 g of ethanolamine were added dropwise and the medium was refluxed for 30 minutes. After cooling to room temperature, the yellow precipitate was filtered off. This precipitate was rinsed with diisopropyl ether. After drying under vacuum over phosphorus pentoxide, 14.2 g of 7-β-hydroxyethylamino-5-methyl-3-nitropyrazolo[1,5-a]pyrimidine were obtained in the form of yellow crystals. (Yield=86%, melting point=231° C.).

Provenance & Evidence