1,4-Dioxane hydrochloride → HCID 69697249, compound

HRID 1870822Notes

Reaction equation

HRID 1870822 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([C:10]2[CH:14]=[C:13]([N:15]=[C:16]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[N:17]=[C:18]([NH2:25])[N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[O:12][N:11]=2)[CH3:9])[CH:5]=[CH:4][C:3]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.[ClH:38].O1CCOCC1>O1CCOCC1>[ClH:38].[F:1][C:2]1[CH:7]=[C:6]([CH:8]([C:10]2[CH:14]=[C:13]([N:15]=[C:16]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[N:17]=[C:18]([NH2:25])[N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[O:12][N:11]=2)[CH3:9])[CH:5]=[CH:4][C:3]=1[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54161962HCID 54161962, compound

Product 1

HCID 69697249HCID 69697249, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (1.66 g) obtained in Example 108 was dissolved in 1,4-dioxane (20 ml) and thereto was added a 4 N hydrogen chloride/1,4-dioxane solution (1.00 ml), after which the resulting mixture was stirred at room temperature for 2 hours, upon which a white precipitate separated. The reaction mixture was heated to 100° C. to dissolve the precipitate and thereafter allowed to slowly cool with stirring. The resulting white precipitate was separated by filtration to obtain the desired compound (1.19 g).

Workup

  1. customseparated
  2. temperatureThe reaction mixture was heated to 100° C.
  3. dissolutionto dissolve the precipitate
  4. temperatureto slowly cool
  5. stirringwith stirring
  6. customThe resulting white precipitate was separated by filtration

Sources & evidence

ORD record
ord-83734bc4d1e84cf9bb9012e66707e5a1
Source dataset
uspto-grants-2000_08
Patent number
US06100260

Reaction notes

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