反应详情

To a solution of 5-benzofurancarbonitrile (Japanese Patent Unexamined Publication No. 9-124,631) (1.30 g) in tetrahydrofuran (5 ml) was added 0.87 M methyl magnesium bromide-tetrahydrofuran solution (21 ml), and the resulting mixture was heated under reflux for 4 hours under a nitrogen atmosphere. The reaction mixture was acidified with conc. sulfuric acid and water was added thereto, after which the resulting mixture was subjected to extraction with diethyl ether. The extract solution was washed with water, dried and then distilled under reduced pressure to remove the solvent. The residue was purified by a silica gel column chromatography to obtain 1-benzofuran-5-yl-ethanone (1.21 g).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 4 hours under a nitrogen atmosphere
3. additionwas added
4. extractionafter which the resulting mixture was subjected to extraction with diethyl ether
5. washThe extract solution was washed with water
6. customdried
7. distillationdistilled under reduced pressure
8. customto remove the solvent
9. customThe residue was purified by a silica gel column chromatography