1-Bromo-4-fluorobenzene → HCID 15205888, compound

HRID 1870864Notes

Reaction equation

HRID 1870864 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=1.C([Li])CCC.[CH3:14][N:15]1[CH:20]2[CH2:21][CH2:22][CH:16]1[CH2:17][C:18](=[O:23])[CH2:19]2>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:18]2([OH:23])[CH2:19][CH:20]3[N:15]([CH3:14])[CH:16]([CH2:22][CH2:21]3)[CH2:17]2)=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 99931-Bromo-4-fluorobenzeneHCID 79038Npc164516HCID 178418339Butyllithium

Product 1

HCID 15205888HCID 15205888, compound

Procedure

The title compound was prepared from 4-bromofluorobenzene (26.3 g, 0.15 mol), n-butyllithium in hexanes (60 mL, 2.5 M; 0.15 mol) and 8-methyl-8-azabicyclo-[3.2.1]octan-3-one (10 g, 71.7 mmol). Yield 9.9 g (59%), m.p. 168.5-170° C.

Sources & evidence

ORD record
ord-cb998e7d455f4d3b8e068b2cc8f71b72
Source dataset
uspto-grants-2000_08
Patent number
US06100275

Reaction notes

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