2-Chloroethyl isocyanate → HCID 18694226, compound

HRID 1870883Notes

Reaction equation

HRID 1870883 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=2)=[C:4]([CH3:18])[CH:3]=1.[Cl:19][CH2:20][CH2:21][N:22]=[C:23]=[O:24]>ClCCl.C1(C)C=CC=CC=1>[Cl:19][CH2:20][CH2:21][NH:22][C:23]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:13]=2)=[C:4]([CH3:18])[CH:3]=1)=[O:24]

Participants

5

Reactant 2

HCID 160352-Chloroethyl isocyanateHCID 21948355Methyl 4'-amino-2'-methyl[1,1'-biphenyl]-4-carboxylate

Product 1

HCID 18694226HCID 18694226, compoundYield 69.6%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

Methyl 4'-amino-2'-methylbiphenyl-4-carboxylate (D2) (1.00 g, 4.1 mmol) and 2-chloroethylisocyanate (0.39 ml, 4.5 mmol) were stirred in dichloromethane (20 ml) for 72 h. The suspension was then diluted with toluene (20 ml), and the solid was filtered off and dried. This gave the title compound (0.99 g, 69%) as a cream solid.

Workup

  1. filtrationthe solid was filtered off
  2. customdried

Sources & evidence

ORD record
ord-020279eefee143cb96120673600c615a
Source dataset
uspto-grants-2000_08
Patent number
US06100272

Reaction notes

Loading…