Phthalide → 2-(4-Bromo-3-methylphenyl)-2,3-dihydroisoindol-1-one

HRID 1870888Notes

Reaction equation

[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[C:10]1([C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]O1)=[O:11]>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]2[CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:10]2=[O:11])=[CH:4][C:3]=1[CH3:9]

Participants

Reactant 2

HCID 6885Phthalide

HCID 233594-Bromo-3-methylaniline

Product 1

HCID 186942202-(4-Bromo-3-methylphenyl)-2,3-dihydroisoindol-1-one

Procedure

The title compound was prepared from 4-bromo-3-methylaniline and phthalide using a similar procedure to Description 20, as a white solid (76%).

Sources & evidence

ORD record: ord-2942e97b11cd4411b9bdfc911bd297a0
Source dataset: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06100272

Reaction notes

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