HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,6-Tetrahydro-1-methylpyridine-4-methanol → 1-Acetyl-5-bromo-6-[(1-methyl-1,2,5,6-tetrahydropyridine-4-yl)methoxy]indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,6-Tetrahydro-1-methylpyridine-4-methanol | HCID 118921 | — |
| Reactant | 1-Acetyl-5-bromo-6-hydroxyindoline | HCID 18694293 | — |
| Product | 1-Acetyl-5-bromo-6-[(1-methyl-1,2,5,6-tetrahydropyridine-4-yl)methoxy]indoline | HCID 18694266 | — |
Reaction Steps
The title compound was prepared from 1-acetyl-5-bromo-6-hydroxyindoline (D64) and 1-methyl-1,2,5,6-tetrahydropyridine-4-methanol (J. Med. Chem., 1988, 31, 545) using the procedure of Description 8a in WO96/19477. The product was purified by acid/base extraction, then used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100272 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-d5fd90c94a4649478697e65a89c1f8b7 |
| Source note | uspto-grants-2000_08 |