Ammonia → HCID 10085156, compound

HRID 1870940Notes

Reaction equation

HRID 1870940 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([C:19](OC)=[O:20])[C:12]=3[N:11]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH3:23]>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([NH2:23])=[O:20])[C:12]=3[N:11]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 10661692HCID 10661692, compound

Product 1

HCID 10085156HCID 10085156, compound

Procedure

Following standard procedure C, methyl 2-(4'-nitrophenyl)-1-H-benzimidazole-4-carboxylate was dissolved in liquid ammonia and heated under constant volume in a pressure vessel. The product was purified by column chromatography from dichloromethane/methanol 99:1 and recrystallised from methanol.

Workup

  1. temperatureheated under constant volume in a pressure vessel
  2. customThe product was purified by column chromatography from dichloromethane/methanol 99:1
  3. customrecrystallised from methanol

Sources & evidence

ORD record
ord-d0c98ff7004d48af9bc07b314dcb5694
Source dataset
uspto-grants-2000_08
Patent number
US06100283

Reaction notes

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