Ammonia → HCID 10852098, compound

HRID 1870941Notes

Reaction equation

HRID 1870941 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([C:9]2[NH:13][C:12]3[CH:14]=[CH:15][CH:16]=[C:17]([C:18](OC)=[O:19])[C:11]=3[N:10]=2)[CH:6]=[CH:7][CH:8]=1.[NH3:24]>>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([C:9]2[NH:13][C:12]3[CH:14]=[CH:15][CH:16]=[C:17]([C:18]([NH2:24])=[O:19])[C:11]=3[N:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 10786006HCID 10786006, compound

Product 1

HCID 10852098HCID 10852098, compound

Procedure

Following standard procedure C, the acetate salt of methyl 2-(3'-trifluoromethylphenyl)-1-H-benzimidazole-4-carboxylate (134.8 mg, 0.358 mmol) was treated with excess liquid ammonia in a sealed vessel. The product was purified by recrystallisation from methanol, to yield off-white needles. (78 mg, 72%).

Workup

  1. customThe product was purified by recrystallisation from methanol
  2. customto yield off-white needles

Sources & evidence

ORD record
ord-f20339c665e8441d9c38cad5e6e9f279
Source dataset
uspto-grants-2000_08
Patent number
US06100283

Reaction notes

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