Trimethylsilyl isocyanate → HCID 54376510, compound

HRID 1870961Notes

Reaction equation

HRID 1870961 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[C:11](=[CH:14][C:15]3[C:23]4[C:18](=[CH:19][C:20]([Cl:25])=[CH:21][C:22]=4[Cl:24])[NH:17][C:16]=3[C:26]([OH:28])=[O:27])[CH2:10][N:9]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:4][CH:3]=1.C[Si]([N:40]=[C:41]=[O:42])(C)C>O1CCCC1>[C:32]([O:31][C:29]([N:9]1[CH2:10][C:11](=[CH:14][C:15]2[C:23]3[C:18](=[CH:19][C:20]([Cl:25])=[CH:21][C:22]=3[Cl:24])[NH:17][C:16]=2[C:26]([OH:28])=[O:27])[C:12](=[O:13])[N:8]1[C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:41]([NH2:40])=[O:42])=[CH:3][CH:4]=1)=[O:30])([CH3:35])([CH3:34])[CH3:33]

Participants

4

Reactant 2

HCID 70696Trimethylsilyl isocyanateHCID 53927932HCID 53927932, compound

Product 1

HCID 54376510HCID 54376510, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of example 16 (0.070 g) in tetrahydrofuran (4 ml) under nitrogen at room temperature was added trimethylsilylisocyanate (0.080 ml). The solution was refluxed for 4 hrs, after which time the product was seen to precipitate from the solution. The solid was filtered off and washed with tetrahydrofuran (10 ml) affording the title compound as an orange solid. (0.042 g).

Workup

  1. temperatureThe solution was refluxed for 4 hrs
  2. customto precipitate from the solution
  3. filtrationThe solid was filtered off
  4. washwashed with tetrahydrofuran (10 ml)

Sources & evidence

ORD record
ord-2084c79cedb043389bd338dd7084f37b
Source dataset
uspto-grants-2000_08
Patent number
US06100289

Reaction notes

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