HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorotoluene → HCID 10130667, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorotoluene | HCID 7810 | — |
| Reactant | Dibutylamine | HCID 8148 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 10130667 | HCID 10130667 | 90% |
Reaction Steps
The above general procedure was followed using 4-chlorotoluene (126 mg, 1.00 mmol) and dibutylamine (129 mg, 1.00 mmol) with 1 mol % Pd(dba)2 and 0.8 mol % tri-t-butylphosphine in 1.0 mL of toluene. After 4 hours at 70° C., the reaction mixture was adsorbed onto silica gel and chromatographed with 2% ethyl acetate/hexanes to give 196 mg (90%) of N,N-dibutyl-p-toluidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100398 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-15ba19e107ce4030a86c0434522e3092 |
| Source note | uspto-grants-2000_08 |